A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
Identifieur interne : 000034 ( 1968/Analysis ); précédent : 000033; suivant : 000035A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
Auteurs : Ying Wu [République populaire de Chine] ; Myungsam Cho [Corée du Sud] ; David Shore [États-Unis] ; Manki Song [Corée du Sud] ; Jungah Choi [Corée du Sud] ; Tao Jiang [République populaire de Chine] ; Yong-Qiang Deng [République populaire de Chine] ; Melissa Bourgeois [États-Unis] ; Lynn Almli [États-Unis] ; Hua Yang [États-Unis] ; Li-Mei Chen [États-Unis] ; Yi Shi [République populaire de Chine] ; Jianxu Qi [République populaire de Chine] ; An Li [République populaire de Chine] ; Kye Sook Yi [Corée du Sud] ; Minseok Chang [Corée du Sud] ; Jin Soo Bae [Corée du Sud] ; Hyunjoo Lee [Corée du Sud] ; Jiyoung Shin [Corée du Sud] ; James Stevens [États-Unis] ; Seoungsuh Hong [Corée du Sud] ; Cheng-Feng Qin [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; Shin Jae Chang [Corée du Sud] ; Ruben O. Donis [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2015.
Abstract
Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and antigenic drift in a particular HA. Here we present a broadly neutralizing human monoclonal antibody with an unusual binding modality. The antibody, designated CT149, was isolated from convalescent patients infected with pandemic H1N1 in 2009. CT149 is found to neutralize all tested group 2 and some group 1 influenza A viruses by inhibiting low pH-induced, HA-mediated membrane fusion. It promotes killing of infected cells by Fc-mediated antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. X-ray crystallographic data reveal that CT149 binds primarily to the fusion domain in HA2, and the light chain is also largely involved in binding. The epitope recognized by this antibody comprises amino-acid residues from two adjacent protomers of HA. This binding characteristic of CT149 will provide more information to support the design of more potent influenza vaccines.
Url:
DOI: 10.1038/ncomms8708
PubMed: 26196962
PubMed Central: 4518248
Affiliations:
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PMC:4518248Le document en format XML
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Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cho, Myungsam" sort="Cho, Myungsam" uniqKey="Cho M" first="Myungsam" last="Cho">Myungsam Cho</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shore, David" sort="Shore, David" uniqKey="Shore D" first="David" last="Shore">David Shore</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>International Vaccine Institute</institution>, Seoul 151-919,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Jungah" sort="Choi, Jungah" uniqKey="Choi J" first="Jungah" last="Choi">Jungah Choi</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>International Vaccine Institute</institution>, Seoul 151-919,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Yong Qiang" sort="Deng, Yong Qiang" uniqKey="Deng Y" first="Yong-Qiang" last="Deng">Yong-Qiang Deng</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourgeois, Melissa" sort="Bourgeois, Melissa" uniqKey="Bourgeois M" first="Melissa" last="Bourgeois">Melissa 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Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qi, Jianxu" sort="Qi, Jianxu" uniqKey="Qi J" first="Jianxu" last="Qi">Jianxu Qi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, An" sort="Li, An" uniqKey="Li A" first="An" last="Li">An Li</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Veterinary Medicine, Guangxi University</institution>, Nanning 530004,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yi, Kye Sook" sort="Yi, Kye Sook" uniqKey="Yi K" first="Kye Sook" last="Yi">Kye Sook Yi</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang, Minseok" sort="Chang, Minseok" uniqKey="Chang M" first="Minseok" last="Chang">Minseok Chang</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bae, Jin Soo" sort="Bae, Jin Soo" uniqKey="Bae J" first="Jin Soo" last="Bae">Jin Soo Bae</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Hyunjoo" sort="Lee, Hyunjoo" uniqKey="Lee H" first="Hyunjoo" last="Lee">Hyunjoo Lee</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Jiyoung" sort="Shin, Jiyoung" uniqKey="Shin J" first="Jiyoung" last="Shin">Jiyoung Shin</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Seoungsuh" sort="Hong, Seoungsuh" uniqKey="Hong S" first="Seoungsuh" last="Hong">Seoungsuh Hong</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Cheng Feng" sort="Qin, Cheng Feng" uniqKey="Qin C" first="Cheng-Feng" last="Qin">Cheng-Feng Qin</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC)</institution>, Beijing 102206,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang, Shin Jae" sort="Chang, Shin Jae" uniqKey="Chang S" first="Shin Jae" last="Chang">Shin Jae Chang</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26196962</idno><idno type="pmc">4518248</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518248</idno><idno type="RBID">PMC:4518248</idno><idno type="doi">10.1038/ncomms8708</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000093</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000093</idno><idno type="wicri:Area/Pmc/Curation">000093</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000093</idno><idno type="wicri:Area/Pmc/Checkpoint">000429</idno><idno 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100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cho, Myungsam" sort="Cho, Myungsam" uniqKey="Cho M" first="Myungsam" last="Cho">Myungsam Cho</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shore, David" sort="Shore, David" uniqKey="Shore D" first="David" last="Shore">David Shore</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>International Vaccine Institute</institution>, Seoul 151-919,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Jungah" sort="Choi, Jungah" uniqKey="Choi J" first="Jungah" last="Choi">Jungah Choi</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>International Vaccine Institute</institution>, Seoul 151-919,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deng, Yong Qiang" sort="Deng, Yong Qiang" uniqKey="Deng Y" first="Yong-Qiang" last="Deng">Yong-Qiang Deng</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bourgeois, Melissa" sort="Bourgeois, Melissa" uniqKey="Bourgeois M" first="Melissa" last="Bourgeois">Melissa Bourgeois</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Almli, Lynn" sort="Almli, Lynn" uniqKey="Almli L" first="Lynn" last="Almli">Lynn Almli</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Hua" sort="Yang, Hua" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qi, Jianxu" sort="Qi, Jianxu" uniqKey="Qi J" first="Jianxu" last="Qi">Jianxu Qi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, An" sort="Li, An" uniqKey="Li A" first="An" last="Li">An Li</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Veterinary Medicine, Guangxi University</institution>, Nanning 530004,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yi, Kye Sook" sort="Yi, Kye Sook" uniqKey="Yi K" first="Kye Sook" last="Yi">Kye Sook Yi</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang, Minseok" sort="Chang, Minseok" uniqKey="Chang M" first="Minseok" last="Chang">Minseok Chang</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bae, Jin Soo" sort="Bae, Jin Soo" uniqKey="Bae J" first="Jin Soo" last="Bae">Jin Soo Bae</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Hyunjoo" sort="Lee, Hyunjoo" uniqKey="Lee H" first="Hyunjoo" last="Lee">Hyunjoo Lee</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Jiyoung" sort="Shin, Jiyoung" uniqKey="Shin J" first="Jiyoung" last="Shin">Jiyoung Shin</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hong, Seoungsuh" sort="Hong, Seoungsuh" uniqKey="Hong S" first="Seoungsuh" last="Hong">Seoungsuh Hong</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Cheng Feng" sort="Qin, Cheng Feng" uniqKey="Qin C" first="Cheng-Feng" last="Qin">Cheng-Feng Qin</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology</institution>, Beijing 100071,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Center for Influenza Research and Early-warning, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences</institution>, No. 1 West Beichen Road, Beijing 100101,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a9"><institution>Office of Director-General, Chinese Center for Disease Control and Prevention (China CDC)</institution>, Beijing 102206,<country>China</country>.</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chang, Shin Jae" sort="Chang, Shin Jae" uniqKey="Chang S" first="Shin Jae" last="Chang">Shin Jae Chang</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Biotechnology Research Institute, Celltrion, Inc.</institution>, Incheon 406-840,<country>South Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Influenza Division, Centers for Disease Control and Prevention</institution>, Atlanta, Georgia 30333,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Effective annual influenza vaccination requires frequent changes in vaccine composition due to both antigenic shift for different subtype hemagglutinins (HAs) and antigenic drift in a particular HA. Here we present a broadly neutralizing human monoclonal antibody with an unusual binding modality. The antibody, designated CT149, was isolated from convalescent patients infected with pandemic H1N1 in 2009. CT149 is found to neutralize all tested group 2 and some group 1 influenza A viruses by inhibiting low pH-induced, HA-mediated membrane fusion. It promotes killing of infected cells by Fc-mediated antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. X-ray crystallographic data reveal that CT149 binds primarily to the fusion domain in HA2, and the light chain is also largely involved in binding. The epitope recognized by this antibody comprises amino-acid residues from two adjacent protomers of HA. This binding characteristic of CT149 will provide more information to support the design of more potent influenza vaccines.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. 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Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laskowski, R A" uniqKey="Laskowski R">R. A. Laskowski</name></author><author><name sortKey="Macarthur, M W" uniqKey="Macarthur M">M. W. Macarthur</name></author><author><name sortKey="Moss, D S" uniqKey="Moss D">D. S. Moss</name></author><author><name sortKey="Thornton, J M" uniqKey="Thornton J">J. M. Thornton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name></noRegion><name sortKey="Deng, Yong Qiang" sort="Deng, Yong Qiang" uniqKey="Deng Y" first="Yong-Qiang" last="Deng">Yong-Qiang Deng</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Jiang, Tao" sort="Jiang, Tao" uniqKey="Jiang T" first="Tao" last="Jiang">Tao Jiang</name><name sortKey="Li, An" sort="Li, An" uniqKey="Li A" first="An" last="Li">An Li</name><name sortKey="Li, An" sort="Li, An" uniqKey="Li A" first="An" last="Li">An Li</name><name sortKey="Qi, Jianxu" sort="Qi, Jianxu" uniqKey="Qi J" first="Jianxu" last="Qi">Jianxu Qi</name><name sortKey="Qi, Jianxu" sort="Qi, Jianxu" uniqKey="Qi J" first="Jianxu" last="Qi">Jianxu Qi</name><name sortKey="Qin, Cheng Feng" sort="Qin, Cheng Feng" uniqKey="Qin C" first="Cheng-Feng" last="Qin">Cheng-Feng Qin</name><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><name sortKey="Shi, Yi" sort="Shi, Yi" uniqKey="Shi Y" first="Yi" last="Shi">Yi Shi</name><name sortKey="Wu, Ying" sort="Wu, Ying" uniqKey="Wu Y" first="Ying" last="Wu">Ying Wu</name></country><country name="Corée du Sud"><noRegion><name sortKey="Cho, Myungsam" sort="Cho, Myungsam" uniqKey="Cho M" first="Myungsam" last="Cho">Myungsam Cho</name></noRegion><name sortKey="Bae, Jin Soo" sort="Bae, Jin Soo" uniqKey="Bae J" first="Jin Soo" last="Bae">Jin Soo Bae</name><name sortKey="Chang, Minseok" sort="Chang, Minseok" uniqKey="Chang M" first="Minseok" last="Chang">Minseok Chang</name><name sortKey="Chang, Shin Jae" sort="Chang, Shin Jae" uniqKey="Chang S" first="Shin Jae" last="Chang">Shin Jae Chang</name><name sortKey="Choi, Jungah" sort="Choi, Jungah" uniqKey="Choi J" first="Jungah" last="Choi">Jungah Choi</name><name sortKey="Hong, Seoungsuh" sort="Hong, Seoungsuh" uniqKey="Hong S" first="Seoungsuh" last="Hong">Seoungsuh Hong</name><name sortKey="Lee, Hyunjoo" sort="Lee, Hyunjoo" uniqKey="Lee H" first="Hyunjoo" last="Lee">Hyunjoo Lee</name><name sortKey="Shin, Jiyoung" sort="Shin, Jiyoung" uniqKey="Shin J" first="Jiyoung" last="Shin">Jiyoung Shin</name><name sortKey="Song, Manki" sort="Song, Manki" uniqKey="Song M" first="Manki" last="Song">Manki Song</name><name sortKey="Yi, Kye Sook" sort="Yi, Kye Sook" uniqKey="Yi K" first="Kye Sook" last="Yi">Kye Sook Yi</name></country><country name="États-Unis"><noRegion><name sortKey="Shore, David" sort="Shore, David" uniqKey="Shore D" first="David" last="Shore">David Shore</name></noRegion><name sortKey="Almli, Lynn" sort="Almli, Lynn" uniqKey="Almli L" first="Lynn" last="Almli">Lynn Almli</name><name sortKey="Bourgeois, Melissa" sort="Bourgeois, Melissa" uniqKey="Bourgeois M" first="Melissa" last="Bourgeois">Melissa Bourgeois</name><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><name sortKey="Donis, Ruben O" sort="Donis, Ruben O" uniqKey="Donis R" first="Ruben O." last="Donis">Ruben O. Donis</name><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name><name sortKey="Yang, Hua" sort="Yang, Hua" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= H2N2V1
|flux= 1968
|étape= Analysis
|type= RBID
|clé= PMC:4518248
|texte= A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
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